Research chemicals only—For laboratory research use only. Not for human consumption, therapeutic, or diagnostic purposes.
    Optimized Aminos
    Free BAC water $50+ · Free US shipping $100+
    99.6% Purity
    GLP-3 RT — research peptide vial, third-party tested 1
    Finished Optimized Aminos 3ml vials on the line

    ✓ HPLC + MS third-party tested

    ✓ Ships from the USA in 1–3 business days

    ✓ Public COA — no request needed

    Finished Optimized Aminos vials with lyophilized cake, capped and moving along the line

    Sealed and capped — one compound per vial

    GLP-3 RT

    For research use only

    SKU RT20 · Purity 99.6%

    99.6% Purity
    Metabolic Research
    $45.00per 10mg

    Size

    Ships from the USA in 1–3 business days
    In Stock(10 available)

    Kit & Save

    1
    • ✓Free US shipping on orders $100+ · ships in 1–3 business days
    • ✓Free Shipment Protection — lost or damaged in transit, we replace it, no return needed
    • ✓Free Bacteriostatic Water on orders $50+
    • ✓30-day replacement guarantee on unopened vials
    • ✓Tested by Janoshik Analytical — HPLC + Mass Spectrometry

    Researchers also added

    Certificate of Analysis (COA)

    Every batch is independently tested by a third-party US lab for HPLC purity and mass-spec identity.

    View third-party COA for GLP-3 RT

    Retatrutide (LY-3437943) reference material — a synthetic peptide investigated in published academic literature as a multi-receptor agonist (MW ~4813 Da). Synthesized at >98% purity with identity confirmed by LC-MS/MS. Supplied as lyophilized powder requiring cold-chain storage at -20°C; cold-pack shipping recommended. Reconstitute with bacteriostatic water. For in-vitro laboratory and analytical research use only. Not a drug, supplement, or therapeutic product. Not for human or animal consumption, ingestion, injection, or any clinical use. Not FDA-approved or evaluated for safety or efficacy.

    Also known as: Retatrutide, LY3437943

    For laboratory research use only. Not for human or animal consumption.

    A new standard for peptide manufacturing

    For research use only

    Step 01

    Sourcing

    Vetted manufacturing partners under documented synthesis controls — not anonymous overseas resellers repacking unknown stock.

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    Research dossier

    Retatrutide (LY3437943) is a novel triple hormone receptor agonist targeting GIP, GLP-1, and glucagon receptors simultaneously. Phase 2 clinical trial data published in the New England Journal of Medicine (2023;389:514-526) reported significant metabolic effects. Research in Diabetes Care (2023;46(5):e124-e125) explored its pharmacokinetic profile. Preclinical studies published in Cell Metabolism (2022;34(12):1823-1835) demonstrated multi-receptor binding properties and downstream signaling cascades in cell-based assays.

    For laboratory research use only. Not for human, veterinary, or diagnostic use.

    Frequently Asked Questions

    For Research Use Only
    Research Use Only: All information below describes in-vitro laboratory findings. GLP-3 RT is not an FDA-approved drug and is not intended for human consumption, therapeutic, or diagnostic use.

    Retatrutide is a triple-agonist synthetic peptide targeting the GLP-1, GIP, and glucagon receptors. Preclinical research has focused on incretin pharmacology and receptor-pathway signaling in metabolic models.

    Where semaglutide and tirzepatide are GLP-1-only and GLP-1/GIP dual-agonists respectively, retatrutide adds the glucagon receptor as a third target — a distinct triple-agonist reference profile for in-vitro comparative work.

    Lyophilized powder in a sealed vial, third-party tested by HPLC + MS. The COA is published publicly on this page. For laboratory research use only — not for human consumption.

    GLP-3 RT (SKU RT20) is independently HPLC and mass-spectrometry tested to 99.6%. A third-party tested Certificate of Analysis is published publicly on this product page — no request required.

    The third-party tested COA for GLP-3 RT is published on this product page. Email email support with your order number if you need the full PDF.

    US orders ship within 1–3 business days from our domestic facility via USPS or UPS, with standard transit of 2–4 business days. Packaging is plain and unbranded.

    Unopened, factory-sealed vials may be eligible for return under the posted refund policy. Contact support with your order number before mailing any product back.

    No. GLP-3 RT is sold strictly for in-vitro laboratory research and educational use only. It is not an FDA-approved drug and is not intended for human consumption, therapeutic, or diagnostic purposes.

    Retatrutide (LY3437943) is a novel triple hormone receptor agonist targeting GIP, GLP-1, and glucagon receptors simultaneously. Phase 2 clinical trial data published in the New England Journal of Medicine (2023;389:514-526) reported significant metabolic effects. Research in Diabetes Care (2023;46(5):e124-e125) explored its pharmacokinetic profile. Preclinical studies published in Cell Metabolism (2022;34(12):1823-1835) demonstrated multi-receptor binding properties and downstream signaling casc

    GLP-3 RT is supplied lyophilized. Reconstitute with bacteriostatic water at your target concentration — our free peptide reconstitution calculator (linked from the menu) computes the exact reconstitution volume for your target concentration. Swirl gently; do not shake. Store the reconstituted vial refrigerated (2–8°C) and use within ~30 days.

    Optimized Aminos manufactures and ships GLP-3 RT from a US facility. Every vial is third-party HPLC and mass-spectrometry tested to 99.6% purity, and orders leave our warehouse within 1–3 business days.
    Selected Size
    99.618%

    Purity

    VariantRetatrutide 20mg
    TestedApr 13, 2026
    View COA

    Quality, verified three ways

    HPLC area % · MS identity

    Chromatographic purity is reported as HPLC area percent, and identity is confirmed by mass spectrometry matching the expected molecular weight. Every result is published as a third-party tested COA.

    Sources & References

    Peer-reviewed research

    New England Journal of Medicine

    Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial

    2023 · DOI: 10.1056/NEJMoa2301972

    Jastreboff AM, et al.

    View Source

    The Lancet

    Retatrutide for People with Type 2 Diabetes — A Phase 2 Trial

    2023

    Rosenstock J, et al.

    View Source

    Nature Medicine

    Retatrutide for Metabolic Dysfunction-Associated Steatotic Liver Disease

    2024

    Sanyal AJ, et al.

    View Source

    Lancet Diabetes & Endocrinology

    Effects of Retatrutide on Body Composition

    2025

    Coskun T, et al.

    View Source

    Related research reading

    Background articles from our research library for GLP-3 RT. For laboratory research context only.

    RESEARCH CHEMICALS ONLY

    This product is intended for laboratory research use only. Not for human consumption, therapeutic, or diagnostic purposes. Not an FDA-approved drug.

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